Introduction
ATP Synthase is a F Type ATPase. This large multisubunit complex reside in inner mitochondrial membrane in eukaryotic cells and in cytoplasmic membrane of prokaryotes. This type of ATPases often use the energy of ATP hydrolysis to pump certain ions through a membrane, but in the case of ATP synthase the reverse is true, that is the preformed ion gradient drives the synthesis of ATP.
Structure
In Electron microscopic studies this elaborate enzyme structurally resembled lollipops.
It is commonly subdivided in two fractions:

• Fo
• F1

Here F in these notations refers to fraction. O in Fo refers to Olygomycine.
Fo remains in membrane while F1 is a peripheral complex and is projected into matrix.

Function
Electron transport chain generates a proton electrochemical gradient. This gradients drives synthesis of ATP.
Molecular mechanism
Upon transportation of proton ion, c subunits in Fo rotates, this rotation induce rotation of gamma subunits. Rotation of gamma subunit induce conformational changes in Beta sunbunits in F1 and this conformational changes is used to generate ATPs.